The FTIR and SAXS studies of influence of a morpholine derivatives on the DMPC-based biological membrane systems

Fourier transformed infrared (FTIR) spectroscopy and small-angle scattering of synchrotron radiation have been used to analyze the influence of two zwitterionic surfactants of the sulfobetaine structure (3-(N-decylmorpholine)-1-propansulfonate and 3-(N-tetradecylmorpholine)-1-propansulfonate) on the...

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Bibliographic Details
Published in:Radiation physics and chemistry (Oxford, England : 1993) England : 1993), 2009-10, Vol.78 (10), p.S129-S133
Main Authors: Kozak, Maciej, Szpotkowski, Kamil, Kozak, Anna, Zieliński, Ryszard, Wieczorek, Daria, Gajda, Michał J., Domka, Ludwik
Format: Article
Language:English
Subjects:
DMPC
Infrared spectroscopy
Phospholipids
Small-angle X-ray scattering
Zwitterionic surfactants
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Summary:Fourier transformed infrared (FTIR) spectroscopy and small-angle scattering of synchrotron radiation have been used to analyze the influence of two zwitterionic surfactants of the sulfobetaine structure (3-(N-decylmorpholine)-1-propansulfonate and 3-(N-tetradecylmorpholine)-1-propansulfonate) on the conformational dynamics of CH 2 and O–P–O groups of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and the structure of phospholipid bilayers. The presence of the surfactant causes changes in the DMPC phase transition temperature. Our small-angle X-ray scattering (SAXS) data analysis implies a gradual disappearance of the lamellar phase typical of DMPC and a probable formation of the bicellar phase or cubic phase in DMPC/surfactants system.
ISSN:0969-806X
1879-0895
DOI:10.1016/j.radphyschem.2009.03.090