Improvement of antibacterial activity of AgNPs@PVA-PVP ternary nanocomposite films followed by gamma-ray irradiation treatment for biomedical applications

• Published in: Radiation physics and chemistry (Oxford, England : 1993) England : 1993), 2025-01, Vol.226, p.112345, Article 112345
• Main Authors: Zeariya, Mohammed G.M., El-Shennawy, Sara Kh.M., Kassar, Ahmed, Humaida, Mohammed Ismail, Kumar, Rakesh, Mohammed, Mostafa Ahmed, El-Morsy, M.A., Menazea, A.A.
• Format: Article
• Language: English
• Subjects: AgNPs@PVA-PVP; Antibacterial activity; Biomedical applications; Cell viability; Gamma rays
• ISSN: 0969-806X
• DOI: 10.1016/j.radphyschem.2024.112345

Our study investigates the influence of several doses of gamma rays on the antibacterial behavior of nanocomposite of silver nanoparticles (AgNPs) doped in a blend of poly (vinyl alcohol) (PVA)-Polyvinyl Pyrrolidone (PVP). AgNPs@PVA-PVP nanocomposite films were fabricated via laser ablation route, and then the synthesized films were subjected to various gamma ray's doses. X-ray diffraction (XRD) data shows a diffraction peak at 2θ = 38° assigned to the existence of AgNPs. Ultraviolet–visible (UV–Vis) results confirm the characteristic peak of silver nanoparticles at 425 nm. The cell viability and antibacterial behavior results confirmed the enhancement in the performance of AgNPs@PVA-PVP composite after irradiated to gamma rays. These values of cell viability have been raised by increasing the dose of gamma rays to 94.5 ± 6.5 % for dose at 70 kGy gamma rays. The values of the inhibition zone of microorganisms were enhanced by raising the doses of gamma rays to 19.5 ± 0.5 and 21.3 ± 0.6 against E. coli and S. aureus respectively specifically for nanocomposite with gamma dose 70 kGy. Thus, the improved antibacterial activity of AgNPs@PVA-PVP nanocomposite could be used in biomedical applications. •AgNPs@PVA/PVP were prepared via laser ablation.•AgNPs@PVA/PVP films exposed to gamma irradiation with various doses.•XRD shows a diffraction peak at 2θ = 38° assigned to the existence of AgNPs.•Cell viability have been raised by increasing the dose of gamma rays to 94.5 ± 6.5 % for dose at 70 KGy.•The inhibition zone was 19.5 ± 0.5 and 21.3 ± 0.6 against E. coli and S. aureus, respectively with gamma dose 70 KGy.