18F-Fluorodeoxyglucose positron emission tomography and serum cytokines and matrix metalloproteinases in the assessment of disease activity in Takayasu's arteritis

To evaluate 18F-fluorodeoxyglucose (18F-FDG) uptake on positron emission tomography–computed tomography (PET–CT) and serum levels of different cytokines and matrix metalloproteinases (MMPs) in patients with Takayasu arteritis (TA) and associations with disease activity. Serum levels of tumor necrosi...

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Bibliographic Details
Published in:Revista Brasileira de Reumatologia 2016-07, Vol.56 (4), p.299-308
Main Authors: Arraes, Anne E.D., de Souza, Alexandre W.S., Mariz, Henrique A., Silva, Neusa P., Torres, Ivone C.G., Pinto, Paula N.V., Lima, Eduardo N.P., Sato, Emilia I.
Format: Article
Language:English
Subjects:
Arterite de Takayasu
Citocinas
Cytokines
Matrix metalloproteinases
Metaloproteinases da matriz
Positron emission tomography scan
Takayasu's arteritis
Tomografia computadorizada
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Summary:To evaluate 18F-fluorodeoxyglucose (18F-FDG) uptake on positron emission tomography–computed tomography (PET–CT) and serum levels of different cytokines and matrix metalloproteinases (MMPs) in patients with Takayasu arteritis (TA) and associations with disease activity. Serum levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-2, IL-6, IL-8, IL-12, IL-18, MMP-3 and MMP-9 were measured in 36 TA patients and 36 controls. Maximum standard uptake value (SUVmax) of 18F-FDG in arterial walls was determined by PET–CT scans. TA patients were classified as active disease, inactive disease and possible active disease. Serum IL-6 and MMP-3 levels were higher in TA patients than in controls (p
ISSN:2255-5021
1809-4570
2255-5021
DOI:10.1016/j.rbre.2015.08.007