Post-polio syndrome: Pathophysiological hypotheses, diagnosis criteria, medication therapeutics

Abstract Post-polio syndrome (PPS) refers to a clinical disorder affecting polio survivors with sequelae years after the initial polio attack. These patients report new musculoskeletal symptoms, loss of muscular strength or endurance. PPS patients are tired, in pain and experience new and unusual mu...

Full description

Saved in:
Bibliographic Details
Published in:Annals of physical and rehabilitation medicine 2010-02, Vol.53 (1), p.34-41
Main Authors: Boyer, F.-C, Tiffreau, V, Rapin, A, Laffont, I, Percebois-Macadré, L, Supper, C, Novella, J.-L, Yelnik, A.-P
Format: Article
Language:English
Subjects:
Biological and medical sciences
Diagnosis
Diagnostic techniques
Diseases of the osteoarticular system
Diseases of the osteoarticular system. Orthopedic treatment
Human viral diseases
Infectious diseases
Internal Medicine
Medical sciences
Pathogénie
Pathophysiology
Physical Medicine and Rehabilitation
Post-polio syndrome
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Syndrome post-poliomyélitique
Therapeutic uses
Traitements médicamenteux
Viral diseases
Viral diseases of the nervous system
Étiologies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Post-polio syndrome (PPS) refers to a clinical disorder affecting polio survivors with sequelae years after the initial polio attack. These patients report new musculoskeletal symptoms, loss of muscular strength or endurance. PPS patients are tired, in pain and experience new and unusual muscular deficits, on healthy muscles as well as deficient muscles initially affected by the Poliovirus . Once a clinical diagnosis is established, the therapeutic options can be discussed. Some pathophysiological mechanisms have been validated by research studies on PPS (inflammatory process in cerebrospinal fluid [CSF] and cytokines of the immune system). Several studies have been conducted to validate medications (pyridostigmine, immunoglobulin, coenzyme Q10) or physical exercises protocols. This article focuses on the relevance and efficacy that can be expected from these therapeutics. Very few studies reported some improvements. Medications combined to individual and supervised exercise training programs are promising therapeutic strategies for PPS patients care management.
ISSN:1877-0657
1877-0665
DOI:10.1016/j.rehab.2009.12.003