Resting motor threshold is a biomarker for motor stroke recovery

Accumulated evidence supports motor evoked potential (MEP) status and neuroimaging measures of corticospinal tract (CST) integrity as useful biomarkers for predicting upper-limb motor recovery. Our aim was to determine which biomarkers among electrophysiological and MRI variables can accurately expl...

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Bibliographic Details
Published in:Annals of physical and rehabilitation medicine 2018-07, Vol.61, p.e26-e26
Main Authors: Kemlin, C., Moulton, E., Lamy, J.C., Rosso, C.
Format: Article
Language:English
Subjects:
Biomarker
Corticospinal excitability
Motor recovery
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Summary:Accumulated evidence supports motor evoked potential (MEP) status and neuroimaging measures of corticospinal tract (CST) integrity as useful biomarkers for predicting upper-limb motor recovery. Our aim was to determine which biomarkers among electrophysiological and MRI variables can accurately explain the motor impairment in subacute/chronic stroke patients. Forty patients (>1 month) were assessed by the Fugl-Meyer score, grip force and the Jebsen Taylor test. A motor composite score was computed with principal component analysis for each patient. In both hemispheres were collected resting motor threshold (rMT), MEP amplitude and latency and fractional anisotropy of the CST (FA-CST). During a motor fMRI paradigm, laterality index was computed within the primary motor cortex and cortico-cerebellar functional connectivity. Lesion volume, age and time since stroke were also collected. Analysis was done with ratio values in patients with MEP in the affected hemisphere (MEP+). First, each variable was tested in simple regression with linear or nonlinear effects. Only significant variables (P
ISSN:1877-0657
1877-0665
DOI:10.1016/j.rehab.2018.05.057