FDG PET/CT appearance of multicentric Castleman's disease mimicking lymphoma

• Published in: Revista Española de medicina nuclear e imagen molecular (English ed.) 2012-05, Vol.31 (3), p.142-144
• Main Authors: Elboga, U, Narin, Y, Urhan, M, Şahin, E
• Format: Article
• Language: English
• Subjects: Angiofollicular lymphoid hyperplasia; Castleman's disease; Enfermedad de Castleman; Hiperplasia linfoide angiofolicular; Positron emission tomography/Computed tomography; Radiology; Tomografía por emisión de positrones/Tomografía computarizada
• ISSN: 2253-8089; 2253-8089
• DOI: 10.1016/j.remnie.2012.06.004

Abstract We report a case of a multicentric form of Castleman's disease with multiple lymph nodes showing intense FDG uptake on whole body scan mimicking non-Hodgkin's lymphoma. In this report, the patient had multiple cervical, mediastinal, hilar, retroperitoneal and abnormal lymph nodes in the groin.18 F-fluorodeoxyglucose positron emission tomography/computed tomography was performed before tissue sampling.18 F-FDG/PET demonstrated multiple areas of increased uptake in cervical, mediastinal, hilar, retroperitoneal and groin lymph nodes, suggesting a generalized disease of the lymphatic system including non-Hodgkin's lymphoma. The final diagnosis is based on the histopathological findings of the material obtained from the cervical lymphadenectomy. The histological diagnosis was multicentric plasma cell variant of Castleman's disease.18 F fluorodeoxyglucose positron emission tomography/computed tomography scan helped to identify the lymph nodes involved throughout the whole body, but did not help to differentiate non-Hodgkin's lymphoma. The clinical conclusions and PET/CT findings are described in this report.