18F-FDG semi-quantitative parameters and biological prognostic factors in locally advanced breast cancer

• Published in: Revista Española de medicina nuclear e imagen molecular (English ed.) 2012-11, Vol.31 (6), p.308-314
• Main Authors: García Vicente, A.M., Soriano Castrejón, Á., Relea Calatayud, F., Muñoz Madero, V., Molina Garrido, M.J., León Martín, A.A., Cordero García, J.M., Pilkington Woll, J.P., Chacón López-Muñiz, I., Palomar Muñoz, A.
• Format: Article
• Language: English
• Subjects: Cáncer de mama localmente avanzado; Factores pronósticos; FDG; Locally advanced breast cancer; PET-TC; PET/CT; Prognostic factors
• ISSN: 2253-8089; 2253-8089
• DOI: 10.1016/j.remnie.2012.10.001

To analyse the correlation between 18F-FDG uptake assessed by PET/CT in locally advanced breast tumours and histopathological and immunohistochemical prognostic factors. Thirty-six women with breast cancer were prospectively evaluated. PET/CT was requested in the initial staging previous to adjuvant chemotherapy (multicentric study). All the patients underwent an 18F-FDG PET/CT with a dual-time-point acquisition. Both examinations were evaluated qualitatively and semiquantitatively with calculation of SUVmax values in PET-1 (SUV-1) and in PET-2 (SUV-2) and the percentage variation of the standard uptake values (retention index) between PET-1 and PET-2. Clinical and metabolic stages were assessed according to TNM classification. The biological prognostic parameters, such as the steroid receptor status, p53 and c-erbB-2 expression, proliferation rate (Ki-67), and grading were determined from tissue of the primary tumour. Metabolic and biological parameters were correlated. A positive relationship was found between semiquantitative metabolic parameters and biological parameters. SUV-1 and SUV-2 values did not show significant statistical correlation (p