Identification of low variability textural features for heterogeneity quantification of 18F-FDG PET/CT imaging

To identify those textural features that are insensitive to both technical and biological factors in order to standardise heterogeneity studies on 18F-FDG PET imaging. Two different studies were performed. First, nineteen series from a cylindrical phantom filled with different 18F-FDG activity conce...

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Bibliographic Details
Published in:Revista Española de medicina nuclear e imagen molecular (English ed.) 2016-11, Vol.35 (6), p.379-384
Main Authors: Cortes-Rodicio, J., Sanchez-Merino, G., Garcia-Fidalgo, M.A., Tobalina-Larrea, I.
Format: Article
Language:English
Subjects:
Heterogeneidad
Heterogeneity
PET/CT
PET/TC
Radiomics
Radiónica
Textura
Texture
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Summary:To identify those textural features that are insensitive to both technical and biological factors in order to standardise heterogeneity studies on 18F-FDG PET imaging. Two different studies were performed. First, nineteen series from a cylindrical phantom filled with different 18F-FDG activity concentration were acquired and reconstructed using three different protocols. Seventy-two texture features were calculated inside a circular region of interest. The variability of each feature was obtained. Second, the data for 15 patients showing non-pathological liver were acquired. Anatomical and physiological features such as patient's weight, height, body mass index, metabolic active volume, blood glucose level, SUV and SUV standard deviation were also recorded. A liver covering region of interest was delineated and low variability textural features calculated in each patient. Finally, a multivariate Spearman's correlation analysis between biological factors and texture features was performed. Only eight texture features analysed show small variability (
ISSN:2253-8089
2253-8089
DOI:10.1016/j.remnie.2016.04.008