Assessment of 68Ga-PSMA-11 PET positivity predictive factors in prostate cancer

Positron emission tomography (PET) studies with 68Ga-PSMA-11 (68Ga-HBED-CC-PSMA) have earned the attention of researchers, due to overexpression of PSMA in the tumoral tissues of prostate cancer. Our aim was to analyze the potential benefit of this radiotracer in the biochemical relapse of prostate...

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Bibliographic Details
Published in:Revista Española de medicina nuclear e imagen molecular (English ed.) 2019-01, Vol.38 (1), p.22-28
Main Authors: Gutiérrez-Cardo, A.L., Pérez Duarte, A., García-Argüello, S.F., López Lorenzo, B., Lillo García, M.E., Valdivielso, P.
Format: Article
Language:English
Subjects:
68Ga-PSMA-11
Antígeno de membrana específico de próstata
Cáncer de próstata
Positron emission tomography
Prostate cancer
Prostate-specific membrane antigen
Tomografía por emisión de positrones
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Summary:Positron emission tomography (PET) studies with 68Ga-PSMA-11 (68Ga-HBED-CC-PSMA) have earned the attention of researchers, due to overexpression of PSMA in the tumoral tissues of prostate cancer. Our aim was to analyze the potential benefit of this radiotracer in the biochemical relapse of prostate cancer. This retrospective analysis included 53 studies, performed on 50 male prostate cancer patients referred due to biochemical recurrence. In all cases, previous imaging techniques were negative or inconclusive. Of the 53 studies, 36 (68%) were positive. Significant differences were found between the positive and negative PET groups in Gleason's scale, PSA levels, PSAdt, late acquisition and the administration of androgen deprivation therapy during treatment (p
ISSN:2253-8089
2253-8089
DOI:10.1016/j.remnie.2018.09.001