Renal denervation for resistant hypertension

Abstract There is a marked contrast between the high prevalence of hypertension and the low rates of adequate control. A subset of patients with suboptimal blood pressure control have drug-resistant hypertension, in the pathophysiology of which chronic sympathetic hyperactivation is significantly in...

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Bibliographic Details
Published in:Revista portuguesa de cardiologia (English ed.) 2015-02, Vol.34 (2), p.125-135
Main Authors: de Sousa Almeida, Manuel, de Araújo Gonçalves, Pedro, Infante de Oliveira, Eduardo, Cyrne de Carvalho, Henrique
Format: Article
Language:English
Subjects:
Cardiovascular
Desnervação renal
Hipertensão arterial
Hypertension
Renal denervation
Sistema nervoso simpático
Sympathetic nervous system
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Summary:Abstract There is a marked contrast between the high prevalence of hypertension and the low rates of adequate control. A subset of patients with suboptimal blood pressure control have drug-resistant hypertension, in the pathophysiology of which chronic sympathetic hyperactivation is significantly involved. Sympathetic renal denervation has recently emerged as a device-based treatment for resistant hypertension. In this review, the pathophysiological mechanisms linking the sympathetic nervous system and cardiovascular disease are reviewed, focusing on resistant hypertension and the role of sympathetic renal denervation. An update on experimental and clinical results is provided, along with potential future indications for this device-based technique in other cardiovascular diseases.
ISSN:2174-2049
2174-2049
DOI:10.1016/j.repce.2014.07.009