Analysis of the Cochrane Review: Fibrates for secondary prevention of cardiovascular disease and stroke

Abstract The influence of fibrates on cardiovascular risk has been the focus of several clinical trials. This Cochrane Collaboration Systematic Review evaluated the efficacy of fibrates for secondary prevention of cardiovascular events and stroke, analyzing 13 randomized controlled trials, in a tota...

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Bibliographic Details
Published in:Revista portuguesa de cardiologia (English ed.) 2017-01, Vol.36 (1), p.55-58
Main Authors: Pires da Rosa, Gilberto, Libânio, Diogo, Azevedo, Luís Filipe
Format: Article
Language:English
Subjects:
Acidente vascular cerebral
Cardiovascular
Cardiovascular events
Eventos cardiovasculares
Fibrates
Fibratos
Prevenção secundária
Revisão sistemática
Secondary prevention
Stroke
Systematic review
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Summary:Abstract The influence of fibrates on cardiovascular risk has been the focus of several clinical trials. This Cochrane Collaboration Systematic Review evaluated the efficacy of fibrates for secondary prevention of cardiovascular events and stroke, analyzing 13 randomized controlled trials, in a total of 16 112 participants with a history of cardiovascular disease. Fibrates showed a protective effect for the composite outcome of non-fatal stroke, non-fatal myocardial infarction (MI) and vascular death, mainly due to reduction in the risk of non-fatal or fatal MI. Nonetheless, these results largely relied on studies including clofibrate, a drug withdrawn from the market in 2002. No statistically significant differences regarding adverse events were found between fibrates and placebo. Although insufficient to support the routine prescription of fibrates in this setting, this evidence should be taken into account when deciding on lipid-modifying therapy in dyslipidemic patients with a history of cardiovascular disease.
ISSN:2174-2049
2174-2049
DOI:10.1016/j.repce.2016.05.009