Melamine in prenatal and postnatal organs in rats

► Pharmacokinetics of melamine in prenatal and postnatal organs was studied in rats. ► Late pregnancy and early infants had the highest distribution of melamine. ► Melamine significantly accumulated in postnatal kidneys at 2-week. Melamine can be transferred to fetus in utero through placenta and to...

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Published in:Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2013-01, Vol.35, p.40-47
Main Authors: Chu, Ching Yan, Chu, Kai On, Ho, Chung Shun, Kwok, Sung Shing, Chan, Ho Ming, Fung, Kwok Pui, Wang, Chi Chiu
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Distribution
Female
Fetus - metabolism
Food Safety
Infants
Kidney - metabolism
Maternal-Fetal Exchange
Melamine
Pharmacokinetics
Pregnancy
Rats
Rats, Sprague-Dawley
Resins, Synthetic - pharmacokinetics
Tissue Distribution
Triazines - blood
Triazines - pharmacokinetics
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Summary:► Pharmacokinetics of melamine in prenatal and postnatal organs was studied in rats. ► Late pregnancy and early infants had the highest distribution of melamine. ► Melamine significantly accumulated in postnatal kidneys at 2-week. Melamine can be transferred to fetus in utero through placenta and to infant ex utero by breast feeding. In this study, we characterized the pharmacokinetics of melamine in prenatal and postnatal organs in rats. Single bolus of melamine was administered to pregnant rats at different gestational stages and to infants at different postnatal stages. Distribution of melamine in maternal serum was about 30% higher in late pregnancy than that in early pregnancy; and it was 2 folds higher in postnatal serum in early infants in young adulthood. Distribution of melamine in all postnatal organs was higher than that in prenatal organs. Postnatal kidneys in early infants had the highest maximum concentration and the lowest clearance of melamine than the other postnatal organs. It may relate to the high vulnerability to the toxicity of melamine in this population.
ISSN:0890-6238
1873-1708
DOI:10.1016/j.reprotox.2012.06.003