Cationic liposomes containing antioxidants reduces pulmonary injury in experimental model of sepsis

Highlights • In the present study, the potential clinical applicability of encapsulation of antioxidants in liposomes is investigated for mitigation of pulmonary injury and alveolar macrophage death by free-radical-related mechanisms. • This co-administration significantly reduced pulmonary damage by...

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Bibliographic Details
Published in:Respiratory physiology & neurobiology 2016-09, Vol.231, p.55-62
Main Authors: Galvão, Andre Martins, Galvão, Júlia Siqueira, Pereira, Marcela Araújo, Cadena, Pabyton Gonçalves, Magalhães, Nereide Stella Santos, Fink, James B, Andrade, Armele Fátima Dornelas de, Castro, Celia Maria Machado Barbosa de, Maia, Maria Bernadete Souza
Format: Article
Language:English
Subjects:
Antioxidant
Liposome
Medical Education
Oxidative stress
Pulmonary injury
Pulmonary/Respiratory
Sepsis
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Summary:Highlights • In the present study, the potential clinical applicability of encapsulation of antioxidants in liposomes is investigated for mitigation of pulmonary injury and alveolar macrophage death by free-radical-related mechanisms. • This co-administration significantly reduced pulmonary damage by decreasing superoxide anion production, lipid peroxidation, protein carbonyls, and improved survival.
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2016.06.001