Vasopressors are essential during cardiopulmonary resuscitation in rats: Is vasopressin superior to adrenaline?

Summary Background Vasopressors are recommended for cardiopulmonary resuscitation (CPR) after cardiac arrest. In order to assess possible benefits regarding neurological recovery, vasopressin versus adrenaline and the combination of both was tested against placebo in a cardiac arrest model in rats....

Full description

Saved in:
Bibliographic Details
Published in:Resuscitation 2007-01, Vol.72 (1), p.137-144
Main Authors: Popp, Erik, Vogel, Peter, Teschendorf, Peter, Böttiger, Bernd W
Format: Article
Language:English
Subjects:
Adrenaline
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Animals
Apoptosis
Biological and medical sciences
Blood Pressure - drug effects
Blood. Blood coagulation. Reticuloendothelial system
Brain - pathology
Cardiac arrest
Cardiopulmonary Resuscitation
Cardiopulmonary resuscitation (CPR)
Drug Therapy, Combination
Emergency
Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care
Epinephrine - administration & dosage
Epinephrine - therapeutic use
Global cerebral ischaemia
Heart Arrest - mortality
Heart Arrest - therapy
In Situ Nick-End Labeling
Intensive care medicine
Male
Medical sciences
Pharmacology. Drug treatments
Random Allocation
Rats
Rats, Wistar
Retrograde Degeneration
Vasoconstrictor Agents - administration & dosage
Vasoconstrictor Agents - therapeutic use
Vasopressin
Vasopressins - administration & dosage
Vasopressins - therapeutic use
Vasopressor
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Background Vasopressors are recommended for cardiopulmonary resuscitation (CPR) after cardiac arrest. In order to assess possible benefits regarding neurological recovery, vasopressin versus adrenaline and the combination of both was tested against placebo in a cardiac arrest model in rats. Methods Under anaesthesia with halothane and N2 O, cardiac arrest was initiated via transoesophageal electrical fibrillation. After 7 min of global ischaemia, CPR was performed by external chest compression combined with defibrillation. Animals were randomly assigned to three groups receiving adrenaline, vasopressin and a combination of both ( n = 15 per group) versus placebo ( n = 8). At 1, 3 and 7 days animals were tested according to a neurological deficit score (NDS). After 7 days of reperfusion, coronal brain sections were analysed by Nissl- and TUNEL-staining. Viable as well as TUNEL-positive neurons were counted in the hippocampal CA-1 sector. For statistical analysis, the log rank and the Kruskal–Wallis ANOVA test were used. All data are given as mean ± S.D.; a p -value
ISSN:0300-9572
1873-1570
DOI:10.1016/j.resuscitation.2006.05.015