Multiple Vertebral Fractures in Young Man as First Manifestation of Systemic Mastocytosis

Systemic mastocytosis (SM) is a clonal disease of mast cell progenitors from the bone marrow. The clinical picture varies from asymptomatic forms (indolent) to a highly aggressive form with a very short (mast cell leukemia) survival. Between 28 and 34% of patients with SM are related to bone conditi...

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Bibliographic Details
Published in:Reumatología clinica (Barcelona) 2017-03, Vol.13 (2), p.107-109
Main Authors: Carrasco Cubero, Carmen, Chamizo Carmona, Eugenio
Format: Article
Language:English
Subjects:
Fracturas vertebrales
Male osteoporosis
Mastocitosis sistémica
Osteoporosis del varón
Systemic mastocytosis
Vertebral fractures
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Description
Summary:Systemic mastocytosis (SM) is a clonal disease of mast cell progenitors from the bone marrow. The clinical picture varies from asymptomatic forms (indolent) to a highly aggressive form with a very short (mast cell leukemia) survival. Between 28 and 34% of patients with SM are related to bone condition at the time of diagnosis and 16% have symptomatic fractures. The presentation of SM as clinical vertebral fractures in young men is rare. Here, we describe a case of established osteoporosis as the only manifestation of SM. La mastocitosis sistémica (MS) es una enfermedad clonal de los progenitores mastocíticos de la médula ósea. El cuadro clínico varía desde una forma asintomática (indolente) hasta una forma altamente agresiva con una supervivencia muy corta (leucemia de mastocitos). Un 28-34% de los pacientes con MS tiene síntomas relacionados con la afección ósea en el momento del diagnóstico y el 16% fracturas. La presentación de MS como fracturas vertebrales clínicas en varones jóvenes no es frecuente. A continuación describimos un caso de osteoporosis establecida como única manifestación de MS.
ISSN:2173-5743
2173-5743
DOI:10.1016/j.reumae.2016.02.008