Neuroimmunological Response in Neuro-Behçet's

Behçet's disease is a chronic, multisystem, autoimmune vasculitis characterised by a triad of key signs. We report the case of a 16-year-old Caucasian girl, who complained of headache, dizziness and paresis of the left side of her body. After physical examination and ancillary tests, she was di...

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Bibliographic Details
Published in:Reumatología clinica (Barcelona) 2019-03, Vol.15 (2), p.117-120
Main Authors: Garcia-Rivero, Alexis Alejandro, Gonzalez-Argote, Javier, Martínez Larrarte, José Pedro, Iglesias González, Ivonne Margarita, Dorta-Contreras, Alberto Juan
Format: Article
Language:English
Subjects:
Barrera sangre-líquido cefalorraquídeo
Behçet's disease
Blood–cerebrospinal fluid barrier
Enfermedad de Behçet
Immunoglobulins
Inmunoglobulinas
Intrathecal synthesis
Neuro-Behçet's disease
Neurobeçhet
Reibergram
Reibergrama
Síntesis intratecal
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Summary:Behçet's disease is a chronic, multisystem, autoimmune vasculitis characterised by a triad of key signs. We report the case of a 16-year-old Caucasian girl, who complained of headache, dizziness and paresis of the left side of her body. After physical examination and ancillary tests, she was diagnosed with Behçet's disease with neurological manifestations (neuro-Behçet's disease). She had a good response to treatment. IgG, IgA, IgM and albumin were quantified in serum and cerebrospinal fluid by single radial immunodiffusion. Intrathecal synthesis was found for the three classes of immunoglobulins. This is the first case in which the Reibergram was used to evaluate the neuroimmunological response in a patient with Behçet's disease, suggesting the use of this diagnostic means for the active phase of the disease. La enfermedad de Behçet es una vasculitis crónica, multisistémica y autoinmune caracterizada por una tríada de signos claves presentes en los pacientes que la padecen. Se presenta una paciente femenina, caucásica, de 16 años, con cefalea, mareos y paresia en hemicuerpo izquierdo que, tras examen físico y métodos complementarios, se diagnosticó como enfermedad de Behçet con manifestaciones neurológicas (neurobehçet), y a la que se impuso tratamiento, con buena respuesta. Se cuantificó IgG, IgA, IgM y albúmina en suero y LCR, por inmunodifusión radial simple, encontrándose síntesis intratecal de las 3 clases de inmunoglobulinas mayores. Los hallazgos en este caso constituyen el primer estudio donde se utiliza el reibergrama para evaluar la respuesta neuroinmunológica en un paciente con enfermedad de Behçet, siendo indicativo este medio diagnóstico de fase activa de la enfermedad.
ISSN:2173-5743
2173-5743
DOI:10.1016/j.reumae.2017.02.004