Relationship of IP-10 gene expression to systemic lupus erythematosus activity

To evaluate IP-10 gene expression in patients with SLE, and its possible relationship with disease activity. This study included 120 patients diagnosed with SLE and 30 healthy controls. The relative gene expression of IP-10 was investigated with the Fold Change method, which was correlated with the...

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Bibliographic Details
Published in:Reumatología clinica (Barcelona) 2022-02, Vol.18 (2), p.91-93
Main Authors: Torres-Vázquez, Julián, Uriel Vázquez-Medina, Martín, Comoto-Santacruz, David Alberto, Pradillo-Macias, Mariano Emilio, Muñoz-Monroy, Omar Eloy, Martínez-Cuazitl, Adriana
Format: Article
Language:English
Subjects:
Actividad lúpica
Biomarkers
Chemokine CXCL10 - genetics
CXCL-10
Gene Expression
Humans
INF
IP-10
LES
Lupus activity
Lupus eritematoso sistémico
Lupus Erythematosus, Discoid
Lupus Erythematosus, Systemic - genetics
SLE
Systemic lupus erythematosus
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Summary:To evaluate IP-10 gene expression in patients with SLE, and its possible relationship with disease activity. This study included 120 patients diagnosed with SLE and 30 healthy controls. The relative gene expression of IP-10 was investigated with the Fold Change method, which was correlated with the level of lupus activity evaluated with the SLEDAI 2-K instrument. Different levels of gene expression were found according to the SLE activity (P = 
ISSN:2173-5743
2173-5743
DOI:10.1016/j.reumae.2021.01.001