Is 18F-FDG-PET/CT prognostic factor for survival in patients with small cell lung cancer? Single center experience

• Published in: Revista portuguesa de pneumologia (English ed.) 2013-11, Vol.19 (6), p.260-265
• Main Authors: Inal, A., Kucukoner, M., Kaplan, M.A., Urakcı, Z., Nas, N., Guven, M., Dostbil, Z., Altındag, S., Isıkdogan, A.
• Format: Article
• Language: English
• Subjects: 18F-FDG-PET/CT; Cancro pulmonar de pequenas células; Fatores de prognóstico; Prognostic factors; Small cell lung cancer
• ISSN: 2173-5115; 2173-5115
• DOI: 10.1016/j.rppnen.2013.03.007

Although a number of studies in patients with a variety of malignant tumors have shown that metabolic activity on fluorine-18 deoxyglucose positron emission tomography computed tomography (18F-FDG-PET/CT) is correlated with survival, there are few studies about the impact of 18F-FDG-PET/CT for survival in small cell lung cancer (SCLC) patients. There is still some ambiguity as to whether FDG PET in patients with SCLC will ensure prognostic knowledge for survival. We performed a retrospective analysis of prognostic implication of 18F-FDG-PET/CT in patients with SCLC. We retrospectively reviewed 54 patients with histologically or cytologically proven SCLC who had undergone pre-treatment 18F-FDG-PET/CT scanning between September 2007 and November 2011 in the Dicle University, School of Medicine, Department of Medical Oncology. SUVmax and other potential prognostic variables were chosen for analysis in this study. Univariate and multivariate analyses were conducted to identify prognostic factors associated with survival. Among the eleven variables of univariate analysis, three variables were identified as having prognostic significance: Performance status (p