In vitro antitumour and antibacterial studies of some Pt(IV) dithiocarbamate complexes

A few Pt(IV) complexes of the type [Pt(L) 2Cl 2] [where L = morpholine dithiocarbamate (L 1), aniline dithiocarbamate (L 2), N-(methyl, cyclohexyl) dithiocarbamate (L 3) and N-(ethyl, cyclohexyl) dithiocarbamate (L 4)] were synthesized. The complexes have been characterized by elemental analysis, mo...

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Published in:Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Molecular and biomolecular spectroscopy, 2006-09, Vol.65 (1), p.32-35
Main Authors: Manav, N., Mishra, A.K., Kaushik, N.K.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents
Antibacterial
Antineoplastic Agents
Antitumour
Cell Line, Tumor
Cell Proliferation
Characterisation
Humans
Magnetic Resonance Spectroscopy
Platinum Compounds - chemical synthesis
Platinum Compounds - chemistry
Platinum Compounds - toxicity
Spectral
Spectrophotometry, Infrared
Synthesis
Thiocarbamates - chemical synthesis
Thiocarbamates - chemistry
Thiocarbamates - toxicity
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Summary:A few Pt(IV) complexes of the type [Pt(L) 2Cl 2] [where L = morpholine dithiocarbamate (L 1), aniline dithiocarbamate (L 2), N-(methyl, cyclohexyl) dithiocarbamate (L 3) and N-(ethyl, cyclohexyl) dithiocarbamate (L 4)] were synthesized. The complexes have been characterized by elemental analysis, molar conductance, IR, electronic, 1H and 13C NMR spectroscopic studies. The ligands found to act in monobasic bidentate fashion. Cyclicvoltammetric studies, antibacterial and in vitro antitumour studies were also carried out.
ISSN:1386-1425
DOI:10.1016/j.saa.2005.09.023