Synthesis, spectral characterization and biological activity of metal(II) complexes with 4-aminoantipyrine derivatives

• Published in: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Molecular and biomolecular spectroscopy, 2013-09, Vol.113, p.346-355
• Main Authors: Leelavathy, C., Arul Antony, S.
• Format: Article
• Language: English
• Subjects: Antimicrobial; DNA; Schiff base; SOD; XRD
• ISSN: 1386-1425
• DOI: 10.1016/j.saa.2013.04.055

•Schiff base behaves as a bidentate ligand.•Four metal complexes have been synthesized.•1H NMR, IR, UV–Vis., CV, SEM studies.•Complexes show significant antimicrobial activity.•Complexes have DNA cleaving and SOD activities. Novel metal(II) complexes derived from furfurylidene-4-aminoantipyrine and 2-aminobenzothiazole were synthesized and characterized by spectroscopic (IR, 1H NMR, UV–Vis., ESR and DART-MS) and other analytical methods. IR spectral studies indicate the binding sites of the ligand with the metal ion. Molar conductance data and magnetic susceptibility measurements provide evidence for monomeric and neutral nature of the complexes. The X band ESR spectrum of the Cu(II) complex at 300 and 77K was recorded. The electrochemical behaviour of the complexes in MeCN at 298K was studied. Thermal studies of the ligand and its complexes show the presence of coordinated water in the complexes. The grain size of the complex was calculated by Scherrer formula using powder XRD. The surface morphology of the complexes was studied using SEM. The in vitro biological screening of the ligand and its complexes were tested against bacterial species S. aureus, E. coli, K. pneumoniae, P. vulgaris and P. aeruginosa and fungal species A. niger, R. stolonifer, A. flavus, R. bataicola and C. albicans. The DNA binding and cleavage activity of the ligand and its complexes were studied. Super oxide dismutase (SOD) activities of the ligand and its complexes have also been measured.