Tridentate hydrazone metal complexes derived from cephalexin and 2-hydrazinopyridine: Synthesis, characterization and antibacterial activity

• Published in: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Molecular and biomolecular spectroscopy, 2015-04, Vol.141, p.169-175
• Main Authors: Anacona, J.R., Rincones, Maria
• Format: Article
• Language: English
• Subjects: Antibacterial activity; Cephalexin 2-pyridinylhydrazone ligand; Hydrazone metal complexes; Magnetic and spectral studies; Synthesis hydrazone containing cephalexin
• ISSN: 1386-1425
• DOI: 10.1016/j.saa.2015.01.009

Transition coordination compounds with a tridentate hydrazone ligand (HL) derived from the condensation of cephalexin antibiotic with 2-hydrazinopyridine were synthesized, characterized and screened for antibacterial activity. [Display omitted] •A new Schiff base using cephalexin antibiotic was prepared.•Cephalexin Schiff base transition metal complexes were prepared.•Magnetic, spectroscopic properties and antibacterial activity were studied. Metal(II) coordination compounds of a tridentate hydrazone ligand (HL) derived from the condensation of cephalexin antibiotic with 2-hydrazinopyridine were synthesized. The hydrazone ligand and mononuclear [ML(OAc)(H2O)] (M(II)=Mn, Co, Ni, Cu, Zn, Ag) complexes were characterized by several techniques, including elemental and thermal analysis, molar conductance and magnetic susceptibility measurements, electronic, FT-IR, EPR and 1H NMR spectral studies. The cephalexin 2-pyridinylhydrazone ligand HL behaves as a monoanionic tridentate NNO chelating agent. The biological applications of complexes have been studied on three bacteria strains (Escherichia coli, Acinetobacter baumannii and Enterococcus faecalis) by agar diffusion disc method.