Spectral and photophysical properties of cytisine in acetonitrile – Theory and experiment

Spectral and photophysical properties of (−)-cytisine that is used as a smoking cessation aid, and which derivatives are promising tools in a treatment of neurological diseases, were investigated in acetonitrile, non-specifically interacting solvent with a polarity similar to water. The two chair co...

Full description

Saved in:
Bibliographic Details
Published in:Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Molecular and biomolecular spectroscopy, 2018-10, Vol.203, p.375-382
Main Authors: Krystkowiak, Ewa, Przybył, Anna K., Bayda-Smykaj, Małgorzata, Koput, Jacek, Maciejewski, Andrzej
Format: Article
Language:English
Subjects:
Conformers
Cytisine
Fluorescence
UV–VIS
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Spectral and photophysical properties of (−)-cytisine that is used as a smoking cessation aid, and which derivatives are promising tools in a treatment of neurological diseases, were investigated in acetonitrile, non-specifically interacting solvent with a polarity similar to water. The two chair conformers of cytisine were found the most stable in the ground state S0 and the lowest excited singlet state S1(π,π*), wherein axial one was characterized by a significantly larger abundance, fluorescence lifetime 0.15 ns and fluorescence quantum yield 0.008. The S1(π,π*) excited state of both cytisine conformers deactivated almost exclusively via internal conversion. [Display omitted] •Detailed photophysics of a smoking cessation aid (−)-cytisine in polar environment•Dominance of (−)-cytisine axial chair conformer in the recorded emission•Sufficient fluorescence quantum yield and photostability of (−)-cytisine
ISSN:1386-1425
DOI:10.1016/j.saa.2018.05.080