A new method to predict genotoxic effects based on serum molecular profile

[Display omitted] •Genotoxicity prediction based on serum molecular profile.•Genotoxicity prediction by serum FTIR spectroscopic analysis.•Biomonitoring based on a drop of blood analysis by FTIR spectroscopy. It is critical to develop new methods to assess genotoxic effects in human biomonitoring si...

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Bibliographic Details
Published in:Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Molecular and biomolecular spectroscopy, 2021-07, Vol.255, p.119680, Article 119680
Main Authors: Araújo, Rúben, Ramalhete, Luís, Paz, Hélder, Ladeira, Carina, Calado, Cecília R.C.
Format: Article
Language:English
Subjects:
Biomonitoring
CBMN
FTIR spectroscopy
Genotoxicity
Serum
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Summary:[Display omitted] •Genotoxicity prediction based on serum molecular profile.•Genotoxicity prediction by serum FTIR spectroscopic analysis.•Biomonitoring based on a drop of blood analysis by FTIR spectroscopy. It is critical to develop new methods to assess genotoxic effects in human biomonitoring since the conventional methods are usually laborious, time-consuming, and expensive. It is aimed to evaluate if the analysis of a drop of serum by Fourier Transform Infrared spectroscopy, allow to assess genotoxic effects in occupational exposure to cytostatic drugs in hospital professionals, as obtained by the lymphocyte cytokinesis-block micronucleus assay. It was considered peripheral blood from hospital professionals exposed to cytostatic drugs (n = 22) and from a non-exposed group (n = 36). It was observed that workers occupationally exposed presented a higher number of micronuclei (p 
ISSN:1386-1425
DOI:10.1016/j.saa.2021.119680