Upconversion nanoparticles anchored MnO2 nanosheets for luminescence “turn on” detecting hydrogen peroxide

• Published in: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Molecular and biomolecular spectroscopy, 2023-10, Vol.299, p.122819, Article 122819
• Main Authors: Zhang, Na, Zhang, Wen, Wu, Yilin, Xie, Xusheng, Jiang, Rongli, Luo, Fabao, Zhang, Keying
• Format: Article
• Language: English
• Subjects: Hydrogen peroxide; MnO2 nanosheets; Nanoprobes; Upconversion nanoparticles
• ISSN: 1386-1425
• DOI: 10.1016/j.saa.2023.122819

A upconversion nanoprobe and its application in monitoring H2O2. [Display omitted] •A H2O2 upconversion nanoprobebased on the confined emitters effect and the controllable assembly of DNA strand.•This nanoprobes showed the high sensitivity and selectivity for detecting H2O2.•This nanoprobes could detect H2O2 in serum, lake water and cancer cells. The sensitively and reliably detecting hydrogen peroxide (H2O2) is of significant for biology and environment protection fields. Herein, we reported a high sensitive H2O2 nanoprobe based on upconversion nanoparticles (UCNPs) anchored MnO2 nanosheets. In which, DNA modified NaYF4@NaYF4:Yb,Tm core–shell nanoparticles were anchored onto the MnO2 nanosheets surface via π-π stacking. Owing to the luminescence resonance energy transfer, the blue luminescence of UCNPs was effectively quenched by MnO2 nanosheets, then the luminescence could be restored by adding H2O2 for reducing MnO2 to Mn2+, and achieving a H2O2 concentration-dependent luminescence change, the detection limit could reach to 0.23 nM (S/N = 3). The proposed method could detect H2O2 in serum, lake water and real samples. Thus, a desired upconversion luminescence sensing strategy for detection H2O2 in life and environmental analysis was successfully constructed. It may be provide a potential tool in disease diagnosis and environmental monitoring fields.