Novel design of near-infrared fluorescent sensors for the detection of Hg2+ in living cells and real water samples

[Display omitted] •Two novel near-infrared emissive probes were designed and synthesized for mercury ions detection.•CyHg-Cl probe exhibited high photostability, low background fluorescence and biotoxicity.•Mercury ions in living cells and real water samples were successfully monitored. Mercury sens...

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Published in:Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Molecular and biomolecular spectroscopy, 2024-01, Vol.304, p.123258, Article 123258
Main Authors: Zhang, Yibin, Ge, Hongjing, Sun, Lin, Cheng, Yueting, Xu, Zihan, Gao, Wei, Wang, Boling, Rong, Xiaoqian, Qiu, Xianyu, Li, Jingjing, Fang, Mingxi, Shang, Jinting
Format: Article
Language:English
Subjects:
Live cell imaging
Mercury ions sensing
Near-infrared emission
Real water samples detection
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Summary:[Display omitted] •Two novel near-infrared emissive probes were designed and synthesized for mercury ions detection.•CyHg-Cl probe exhibited high photostability, low background fluorescence and biotoxicity.•Mercury ions in living cells and real water samples were successfully monitored. Mercury sensing and imaging in the bio-system is essential for comprehending its toxicity and therapies. Based on the merocyanine scaffold, we designed and synthesized two novel near-infrared (NIR) fluorescent probes for detecting Hg2+. The release of chloro-substituted merocyanine structure on the probe CyHg-Cl enables fluorescence enhancement rapidly by introducing Hg2+. In addition, the probe CyHg-Cl exhibits NIR emission and a low detection limit of 0.59 µM. Finally, the probe CyHg-Cl was used to detect Hg2+ in live cells and real water samples.
ISSN:1386-1425
DOI:10.1016/j.saa.2023.123258