Second-order scattering sensor based on the Zn0.97La0.03O compound for selective and stable detection of glycated albumin

[Display omitted] •LaZnO SOS sensor has been obtained and characterized.•The sensor presented temporal stability over 60 days.•The SOS signal was resistant to the 6–8 pH range.•LaZnO presented high selectivity.•Low detection limit (LOD = 550 ng/mL). Here, we presented a second-order scattering senso...

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Bibliographic Details
Published in:Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Molecular and biomolecular spectroscopy, 2024-06, Vol.314, p.124176, Article 124176
Main Authors: dos Santos, José Jonathan Soares, Garcia, Ramon Raudel Peña, Soares, Adriano Santana, de Amorim Silva, Elias Gabriel, Neves, Jorge Luiz, Menezes, Thaís Meira
Format: Article
Language:English
Subjects:
Diabetes mellitus
Glycated albumin
Second-order scattering
Sensor
ZnO
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Summary:[Display omitted] •LaZnO SOS sensor has been obtained and characterized.•The sensor presented temporal stability over 60 days.•The SOS signal was resistant to the 6–8 pH range.•LaZnO presented high selectivity.•Low detection limit (LOD = 550 ng/mL). Here, we presented a second-order scattering sensor based on the Zn0.97La0.03O compound (LaZnO) for selective and stable detection of glycated albumin (GA, glycemic long-term biomarker). The LaZnO sample was obtained through the co-precipitation method and then characterized using microscopic and spectroscopic techniques. Furthermore, the selectivity, molecular interference, temporal stability, and pH effects of the LaZnO SOS signal in the absence and presence of GA were investigated. The results indicate the stability of the SOS signal over more than 60 days. Assays conducted within the pH range of 5 to 8 indicate that the detection of GA remains unaffected under the given conditions. Selectivity studies show that the SOS signal of LaZnO is reduced only upon contact with GA, while interference studies show that detection is not affected by other chemical species. Additionally, the calibration curve test showed high sensitivity of the material, with a detection limit of 0.55 µg/ml. All the results suggest that LaZnO can deliver efficiency, selectivity, accuracy, and fast response as a GA biosensor, emphasizing LaZnO’s usefulness in detecting protein biomarkers.
ISSN:1386-1425
DOI:10.1016/j.saa.2024.124176