Insights into the photoactivatable CO releasing properties of dicarbonyl Ru(II) complex with 8-amino quinoline ligand: Experimental and theoretical studies

• Published in: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Molecular and biomolecular spectroscopy, 2024-11, Vol.320, p.124644, Article 124644
• Main Authors: Khaled, Rabaa M., Hegazy, Yara S., Arafa, Mohamed M., Sadek, Muhammed S., Radacki, Krzysztof, A. E. Mostafa, Gamal, Ali, Essam A., Shehab, Ola R., Mansour, Ahmed M.
• Format: Article
• Language: English
• Subjects: Cell viability; dicarbonyl ruthenium(II) complexes; Solvatochromism; Spectral
• ISSN: 1386-1425
• DOI: 10.1016/j.saa.2024.124644

[Display omitted] •Biomolecules have a role in controlling the nature CO depleted species.•The nature of the lowest energy band was verified with the aid of DFT calculations.•The photochemical properties are affected by nature of the solvent. Reaction between the polymeric [RuCl2(CO)2]n and the N,N-bidentate ligand, 8-amino-quinoline (Quin), in methanol, afforded the photoactivated CO releasing molecule with the formula of trans-(Cl,Cl)-[RuCl2(CO)2Quin]. In the presence of biomolecules or in solvents with varying polarity and coordinating abilities, the solvatochromic characteristics and dark stability were investigated. A new board band emerged in the visible spectrum during the illumination, and its position varies according to the type of solvent used, indicating the role of the solvent in controlling the nature of the CO-depleted species. Spectral methods were used in combination with density functional theory simulations to get insight into the local minimum structure and the electronic properties of the Ru(II) complex. The results of the myoglobin assay showed that within the first two hours of illumination, one of the two CO molecules was released. The cytotoxic properties of the Ru(II)-based complex were investigated against normal mice bone marrow stromal cells and malignant human acute monocytic leukaemia cells.