Synergistic properties of sesquiterpene lactones isolated from Centratherum punctatum Cass. in combination with ampicillin against beta-lactam-resistant Gram-negative bacteria

Three known sesquiterpene lactones were isolated from Centratherum punctatum leaf extract. Their antibacterial properties and synergistic effects with ampicillin against drug-resistant Gram-negative bacteria were studied. Individually, they exerted little or no antibacterial activity against the bac...

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Bibliographic Details
Published in:South African journal of botany 2018-07, Vol.117, p.79-82
Main Authors: Chukwujekwu, J.C., Van Heerden, F.R., Van Staden, J.
Format: Article
Language:English
Subjects:
Antibacterial
Beta-lactam resistance
Centratherin
Centratherum punctatum
Synergy
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Summary:Three known sesquiterpene lactones were isolated from Centratherum punctatum leaf extract. Their antibacterial properties and synergistic effects with ampicillin against drug-resistant Gram-negative bacteria were studied. Individually, they exerted little or no antibacterial activity against the bacterial strains. However, when combined with ampicillin, centratherin showed synergistic interaction against both bacterial strains. Centratherin reduced the MIC of ampicillin sixteen-fold. It portrayed potentiating effects when combined with the antibiotics. •Three known sesquiterpene lactones were isolated from Centratherum punctatum.•Compounds displayed weak antibacterial activity against drug-resistant Gram-negative bacteria.•Centratherin potentiated antibacterial activity of ampicillin against both bacterial strains.
ISSN:0254-6299
1727-9321
DOI:10.1016/j.sajb.2018.04.003