Genus Aloe as sources of antidiabetic, antihyperglycemic and hypoglycemic agents: A review

•The paper reviews the antidiabetic potentials of Aloe species.•Aloe vera is the most common species with antidiabetic properties.•Different methods were used to determine their potentials.•Further study is needed to isolate antidiabetic agents from the genus. Of all medicinal plants used to treat a...

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Bibliographic Details
Published in:South African journal of botany 2022-07, Vol.147, p.1070-1077
Main Authors: Kazeem, Mutiu Idowu, Bankole, Habeeb Adebodun, Fatai, Azeez Ayomide, Saibu, Gbemisola Morounke, Wusu, Adedoja Dorcas
Format: Article
Language:English
Subjects:
Aloe
Diabetes mellitus
hyperglycemia
IC50
Streptozotocin
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Summary:•The paper reviews the antidiabetic potentials of Aloe species.•Aloe vera is the most common species with antidiabetic properties.•Different methods were used to determine their potentials.•Further study is needed to isolate antidiabetic agents from the genus. Of all medicinal plants used to treat ailments, the genus Aloe represents one of the commonest. They manage various pathological conditions, including inflammation, infection, cancer and diabetes mellitus. There are specific reports on the hypoglycemic and antidiabetic potential of different species of Aloe. Still, there is a shortage of comprehensive reports which present all Aloe species with antidiabetic properties. This study aims to integrate available information on all Aloe spp. with antidiabetic potentials. Scientific databases such as PubMed, EBSCOhost, Science Direct, Scopus, and Google Scholar, were utilized to search and collect literature for this review. This review revealed that the most common Aloe sp. with antidiabetic potentials is A. vera. It also showed that few studies were carried out in vitro while most were performed in vivo. We can conclude that Aloe spp. is a potent source of antidiabetic agents. Further studies should be conducted to isolate the antidiabetic compounds from the plant.
ISSN:0254-6299
1727-9321
DOI:10.1016/j.sajb.2022.05.041