Violent persons with schizophrenia and comorbid disorders: A functional magnetic resonance imaging study

Abstract The main goal of this functional Magnetic Resonance Imaging (fMRI) study was to verify the hypothesis that seriously violent persons with Sz and the co-morbid diagnoses of an Antisocial Personality Disorder (APD) and a Substance Use Disorder (Sz + APD + SUD) would present a different patter...

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Bibliographic Details
Published in:Schizophrenia research 2007-03, Vol.91 (1), p.97-102
Main Authors: Joyal, C.C, Putkonen, A, Mancini-Marïe, A, Hodgins, S, Kononen, M, Boulay, L, Pihlajamaki, M, Soininen, H, Stip, E, Tiihonen, J, Aronen, H.J
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Antisocial personality disorder
Antisocial Personality Disorder - diagnosis
Antisocial Personality Disorder - epidemiology
Antisocial Personality Disorder - psychology
Biological and medical sciences
Brain - physiopathology
Comorbidity
Diagnosis, Dual (Psychiatry)
fMRI
Humans
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
Personality disorders
Prefrontal Cortex - physiopathology
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - epidemiology
Schizophrenia - physiopathology
Severity of Illness Index
Substance-Related Disorders - diagnosis
Substance-Related Disorders - epidemiology
Violence
Violence - psychology
Violence - statistics & numerical data
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Summary:Abstract The main goal of this functional Magnetic Resonance Imaging (fMRI) study was to verify the hypothesis that seriously violent persons with Sz and the co-morbid diagnoses of an Antisocial Personality Disorder (APD) and a Substance Use Disorder (Sz + APD + SUD) would present a different pattern of prefrontal functioning than seriously violent persons with Sz only. In support with the main hypothesis, frontal basal cortices were significantly less activated in persons with Sz + APD + SUD during the execution of a go/no-go task than in persons with Sz only and non-violent persons without a mental illness. In contrast, significantly higher activations in frontal motor, premotor and anterior cingulate regions were observed in the Sz + APD + SUD group than in the Sz-only group.
ISSN:0920-9964
1573-2509
DOI:10.1016/j.schres.2006.12.014