Relationship of SNAP25 variants with schizophrenia and antipsychotic-induced weight change in large-scale schizophrenia patients

The SNAP25 gene is involved in the development of antipsychotic-induced weight gain (AIWG) or metabolic syndrome during antipsychotics use in Americans and Europeans, but its role in Asians remains unknown. To identify common variants in SNAP25 associated with schizophrenia and evaluate their effect...

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Bibliographic Details
Published in:Schizophrenia research 2020-01, Vol.215, p.250-255
Main Authors: Guan, Fanglin, Zhang, Tianxiao, Han, Wei, Zhu, Li, Ni, Tong, Lin, Huali, Liu, Dan, Chen, Gang, Xiao, Jing, Li, Tao
Format: Article
Language:English
Subjects:
Adult
Antipsychotic Agents - adverse effects
Antipsychotic Agents - pharmacology
Antipsychotic-induced weight gain
Asian Continental Ancestry Group - genetics
Case-Control Studies
Case-control study
China
Common variants
Female
Genetic Predisposition to Disease
Humans
Male
Polymorphism, Single Nucleotide
Schizophrenia - drug therapy
Schizophrenia - genetics
Schizophrenia susceptibility
SNAP25
Synaptosomal-Associated Protein 25 - genetics
Weight Gain - drug effects
Weight Gain - genetics
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Summary:The SNAP25 gene is involved in the development of antipsychotic-induced weight gain (AIWG) or metabolic syndrome during antipsychotics use in Americans and Europeans, but its role in Asians remains unknown. To identify common variants in SNAP25 associated with schizophrenia and evaluate their effects on AIWG and antipsychotic responses in Han Chinese individuals with schizophrenia, we conducted a two-stage case–control study of 3,243 patients and 6,154 healthy controls. 2128 inpatients in the replication stage have received conventional treatment with an antipsychotic monotherapy (Haloperidol, Olanzapine or Risperidone) for 10 weeks at least. Weight change, antipsychotic responses and metabolic indices change were assessed during treatments. Three SNPs were significantly associated with schizophrenia in samples (rs6039769, P = 6.64 × 10−7; rs3787283, P = 0.004283; rs3746544, P = 2.51 × 10−6). Of these, rs6039769 is a novel schizophrenia-associated SNP and is uncorrelated with the other two variants, which have previously been associated with schizophrenia in European-ancestry samples. Rs6039769 was significantly associated with AIWG (P 
ISSN:0920-9964
1573-2509
DOI:10.1016/j.schres.2019.09.015