A novel stochastic reaction-diffusion model of Ca2+ blink in cardiac myocytes

<正>In cardiac myocytes,the sarcoplasmic reticulum（SR）is the main storage organelle of free Ca2+.The concentration of free Ca2+in the SR is 0.5–1.0 mmol/L and is 2–3 orders of magnitude greater than that in the cytosol.The SR is composed of interconnected cisternae（junctional SR,i.e.,JS...

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Published in:Science bulletin (Beijing) 2017-01, Vol.62 (1), p.5-8
Main Authors: Li, Jinghui, Xie, Wenjun, Chen, Xi, Huo, Yunlong, Cheng, Heping, Tan, Wenchang
Format: Article
Language:English
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Summary:<正>In cardiac myocytes,the sarcoplasmic reticulum（SR）is the main storage organelle of free Ca2+.The concentration of free Ca2+in the SR is 0.5–1.0 mmol/L and is 2–3 orders of magnitude greater than that in the cytosol.The SR is composed of interconnected cisternae（junctional SR,i.e.,JSR）and tubules（free SR network,i.e.,FSR）that extend throughout the cytosol[1].Ca2+is released from the JSR into the cytosol via Ca2+release units(CRUs,
ISSN:2095-9273
DOI:10.1016/j.scib.2016.12.001