Ecotoxicity assessment of sodium dimethyldithiocarbamate and its micro-sized metal chelates in Caenorhabditis elegans

• Published in: The Science of the total environment 2020-06, Vol.720, p.137666, Article 137666
• Main Authors: Wang, Yitian, Zhang, Han, Wu, Xiangyu, Xue, Cheng, Hu, Yang, Khan, Asim, Liu, Fuwen, Cai, Lankun
• Format: Article
• Language: English
• Subjects: C. elegans; Chelating agent; Ecological risk; Heavy metal; Sodium dimethyldithiocarbamate
• ISSN: 0048-9697; 1879-1026
• DOI: 10.1016/j.scitotenv.2020.137666

Sodium dimethyldithiocarbamate (SDDC) is a widely used heavy metal chelating agent in harmless treatment of wastewater and hazardous waste, but SDDC and its heavy metal chelates may leak into the environment and bring potential ecological risks. In this study, the model organism Caenorhabditis elegans was used to evaluate the toxic effect of SDDC and its heavy metal Cu, Pb chelates. Multiple endpoints were investigated by subacute exposure to SDDC (0.01–100 mg/L) and micro-sized Cu, Pb chelates of SDDC (1–100 mg/L). Our data indicated that the LC50 value of SDDC was 139.39 mg/L (95% Cl: 111.03, 174.75 mg/L). In addition, SDDC was found that concentration of 1 mg/L is a safe limit value for nematode C. elegans, and concentration above 1 mg/L caused adverse effects on the survival, growth, locomotion behaviors and reactive oxygen species (ROS) production of exposed nematodes. Furthermore, all tested SDDC-Cu and SDDC-Pb chelates had obviously lower toxic effect than untreated Cu, Pb metals. These two chelates also had a lower toxic effect than SDDC agent due to its more stable structure. Moreover, SDDC-Cu had a higher toxic effect than SDDC-Pb at the same concentration. Thus, our results suggest that SDDC as a kind of chelating agent applied in harmless treatment of heavy metals, the safe addition limit should not be exceeded. [Display omitted] •SDDC at concentration of 1 mg/L is a safe limit value for nematode C. elegans.•SDDC (≥1 mg/L) caused adverse effects on survival, growth, behaviors and ROS.•SDDC-Cu and SDDC-Pb chelates had lower toxic effect than Cu and Pb.•SDDC metal chelates had a more stable chemical structure than SDDC.