Severity of anxiety and depression are related to a higher perception of adverse effects of antiepileptic drugs

Abstract After reviewing the negative effects of antiepileptic drugs (AEDs) on general health and quality of life, the Commission on Outcome Measurement from the International League Against Epilepsy (ILAE) recommended incorporating reliable and valid tools in clinical essays in order to achieve a m...

Full description

Saved in:
Bibliographic Details
Published in:Seizure (London, England) England), 2012-10, Vol.21 (8), p.588-594
Main Authors: Gómez-Arias, Bety, Crail-Meléndez, Daniel, López-Zapata, Rosario, Martínez-Juárez, Iris E
Format: Article
Language:English
Subjects:
Adult
Adverse effects
Anticonvulsants - adverse effects
Antiepileptic drugs
Anxiety
Anxiety - complications
Depression
Depression - complications
Epilepsy
Epilepsy - complications
Epilepsy - drug therapy
Epilepsy - psychology
Female
HADS
Humans
LAEP
Male
Mexican
Mexico
Neurology
Scale
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract After reviewing the negative effects of antiepileptic drugs (AEDs) on general health and quality of life, the Commission on Outcome Measurement from the International League Against Epilepsy (ILAE) recommended incorporating reliable and valid tools in clinical essays in order to achieve a more accurate assessment of the subjective adverse effects rate and disease severity when using AEDs. Purpose The aim of this study was to correlate the severity of adverse effects of AEDs, with the presence of anxiety and depression in patients with epilepsy. Methods The Spanish version of the Liverpool Adverse Events Profile (LAEP) and the Hospital Anxiety and Depression Scale (HADS) were applied on 130 consecutive outpatients with epilepsy from the epilepsy clinic at the Mexico's National Institute of Neurology and Neurosurgery. A correlation analysis was carried out to determine if the presence of depression and anxiety was related to the adverse effects of AEDs. The relation between LAEP scores with other epidemiological variables was also assessed. Results Our study found a positive correlation between the LAEP and the HADS scores ( p =
ISSN:1059-1311
1532-2688
DOI:10.1016/j.seizure.2012.06.003