Chemoreceptors as a key to understanding carcinogenesis process

The tissue organization field theory (TOFT) presented completely new, different from the previous one, perspective of research on neoplasm processes. It implicates that secretory neuroepithelial-like cells (NECs), putative chemoreceptors are probably responsible for the control of squamous epithelia...

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Bibliographic Details
Published in:Seminars in cancer biology 2020-02, Vol.60, p.362-364
Main Authors: Satora, Leszek, Mytych, Jennifer, Bilska-Kos, Anna, Kozioł, Katarzyna
Format: Article
Language:English
Subjects:
Animals
Carcinogenesis
Cell Transformation, Neoplastic - genetics
Cell Transformation, Neoplastic - metabolism
Chemoreceptor Cells - metabolism
Chemoreceptors
Disease Susceptibility
Genetic Predisposition to Disease
Gut breathing fish
Humans
Neoplasms - etiology
Neoplasms - metabolism
Neoplasms - pathology
Squamous cells proliferation
TOFT theory
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Summary:The tissue organization field theory (TOFT) presented completely new, different from the previous one, perspective of research on neoplasm processes. It implicates that secretory neuroepithelial-like cells (NECs), putative chemoreceptors are probably responsible for the control of squamous epithelial cells proliferation in the digestive tract during hypoxia in gut breathing fish (GBF). On the other hand, chemoreceptors dysfunction can lead to uncontrolled proliferation and risk of cancer development in mammals, including humans. The studies on NECs like cells (signal capturing and transduction) may be crucial for understanding the processes of controlling the proliferation of squamous epithelial cells in the digestive tract of GBF fish during hypoxia states. This knowledge can contribute to the explanation of cancer processes.
ISSN:1044-579X
1096-3650
DOI:10.1016/j.semcancer.2019.10.003