Gene regulatory networks in differentiation and direct reprogramming of hepatic cells

Liver development proceeds by sequential steps during which gene regulatory networks (GRNs) determine differentiation and maturation of hepatic cells. Characterizing the architecture and dynamics of these networks is essential for understanding how cell fate decisions are made during development, an...

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Bibliographic Details
Published in:Seminars in cell & developmental biology 2017-06, Vol.66, p.43-50
Main Authors: Gérard, Claude, Tys, Janne, Lemaigre, Frédéric P.
Format: Article
Language:English
Subjects:
Animals
Cell Differentiation
Cellular Reprogramming - genetics
Cholangiocyte
Gene Regulatory Networks - genetics
Hepatic cell differentiation
Hepatoblast
Hepatocyte
Hepatocytes - metabolism
Humans
Liver development
Network dynamics
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Summary:Liver development proceeds by sequential steps during which gene regulatory networks (GRNs) determine differentiation and maturation of hepatic cells. Characterizing the architecture and dynamics of these networks is essential for understanding how cell fate decisions are made during development, and for recapitulating these processes during in vitro production of liver cells for toxicology studies, disease modelling and regenerative therapy. Here we review the GRNs that control key steps of liver development and lead to differentiation of hepatocytes and cholangiocytes in mammals. We focus on GRNs determining cell fate decisions and analyse subcircuitry motifs that may confer specific dynamic properties to the networks. Finally, we put our analysis in the perspective of recent attempts to directly reprogram cells to hepatocytes by forced expression of transcription factors.
ISSN:1084-9521
1096-3634
DOI:10.1016/j.semcdb.2016.12.003