Dose of selenium in goat kids and its effect on the antigenic response to Mannheimia haemolytica and oxidative stress

• Published in: Small ruminant research 2017-08, Vol.153, p.171-174
• Main Authors: Díaz-Sánchez, Víctor M., Rodríguez-Patiño, Gabriela, Ramírez-Noguera, Patricia, Ramírez-Bribiesca, J. Efrén, Morales-Álvarez, José F., Revilla-Vázquez, Alma L., López-Arellano, Raquel
• Format: Article
• Language: English
• Subjects: Antigenic response; Goat kids; Oxidative stress; Selenium
• ISSN: 0921-4488; 1879-0941
• DOI: 10.1016/j.smallrumres.2017.06.005

•Selenium supplementation in goat kids improves the humoral immune response to Mannheimia haemolytica.•Subcutaneous doses of 0.25mg Se/kg of live weight (LW) or administration of quick-release intraruminal Se boluses (0.46mg/kg LW) improve the erythrocyte Se concentration.•Selenium promotes cellular modulated responses in order to improve redox status in goat kids.•Oxidative stress levels measured by GSH content, CAT activity and MDA show differences during the first 14days post-dosing with selenium. Selenium (Se) prevents oxidative damage and stimulates the immune system. Currently, there are no data available evaluating the Se-induced antigenic response to Mannheimia haemolytica and oxidative stress in goat kids. Twenty-one 6-month-old male Alpine Goat kids (22.9kg) were immunized against M. haemolytica and divided into 3 groups: Basal diet with no additional Se (CG); Se injected subcutaneously at 0.25mg Se/kg live weight (LW) (SeSG); and Se administered as intraruminal bolus at 0.46mg Se/kg LW (SeBG). Blood samples were taken from the animals in all groups at 0, 14, 28, 42 and 56days post-dosing. Erythrocyte Se levels doubled in SeSG during days 14–28 post-dosing (130.6ng/g Se) as compared to CG. During days 28–42 post-dosing, Se levels decreased (P