CARDIAC BIOMARKERS TROPONIN I AND CK-MB IN EWES AFFECTED BY PREGNANCY TOXEMIA

• Published in: Small ruminant research 2019-08, Vol.177, p.97-102
• Main Authors: de Souza, Leonardo Magno, de Mendonça, Carla Lopes, de ASSIS, Regina Nóbrega, Oliveira Filho, Emanuel Felipe, Araújo Gonçalves, Daniel Nunes, Cavalcante Souto, Rodolfo José, Soares, Pierre Castro, Bastos Afonso, José Augusto
• Format: Article
• Language: English
• Subjects: Cardiac Biomarkers; Cardiac Injury; Ewes; Metabolic Disorders; Pregnancy Toxemia
• ISSN: 0921-4488; 1879-0941
• DOI: 10.1016/j.smallrumres.2019.06.020

•The elevation of β-OHB indices was also an observed condition, reflecting a severe negative energy balance, with lipomobilization, resulting in a disturbance in the metabolism of carbohydrates and fats, with consequent hepatic ketogenesis.•Higher serum concentrations of glucose, cortisol, and enzymatic activities of AST, GGT, and CK were observed in ewes with PT.•The concentration of cTnI in ewes of the PT group was about 20 times higher in the animals that were clinically discharged and more than 30 times higher in the animals that died in relation to the ewes without PT.•Elevations in the concentrations of cardiac biomarkers in sheep with Pregnancy Toxaemia, principally cTnI, may be used as another indicator related to the prognosis of the disease involving cardiac injury. The evaluation of biomarkers of myocardial injury, such as Troponin I (cTnI) and the myocardial band of creatine kinase (CK-MB) has not yet been studied in Brazil, in ewes affected by pregnancy toxemia (PT) in order to verify the clinical condition, study its blood dynamics, as well as its relationship with other markers routinely used to establish the diagnosis. In this context, the objective of this study was to evaluate the effects of the metabolic disorder caused by PT in ewes on cardiac muscle function, evaluating the dynamics of cTnI and CK-MB. Fifty-three ewes with a diagnosis of PT were included, divided into two subgroups, a group of ewes who had PT that evolved to discharge and another group with PT that evolved to death. A third group is formed with 10 ewes with no signs of PT, as Control Group (CG). Higher serum concentrations of cTnI were observed in ewes who had PT and died (1.03 ng/mL) when compared to the group of ewes in the PT group who were clinically discharged (0.71 ng/mL), and these differed from the group of ewes without TP (0.03 ng/mL). The serum concentration of CK-MB in the PT group which died (196.91 U/L) was higher in relation to the control group (50.75 U/L). In the study of the relationship between pairs of variables, positive correlations were observed between serum concentrations of cTnI and CK-MB (r = 0.68, p