The efficacy of iodinated ethyl esters of safflower seed oil (Carthamus tinctorius L.) in the control of iodine deficiency in sheep

• Published in: Small ruminant research 2023-09, Vol.226, p.107043, Article 107043
• Main Authors: Masoudi, Alireza Talebian, Hojati, Seyedeh Fatemeh
• Format: Article
• Language: English
• Subjects: Iodine; Iodine deficiency; Iodine supplement; Iodized fatty acid ethyl esters; Ovine; Thyroid hormones
• ISSN: 0921-4488; 1879-0941
• DOI: 10.1016/j.smallrumres.2023.107043

Iodine is an essential component of the thyroid gland hormones (T3 and T4), necessary for mammalian life. Iodine deficiency leads to inadequate thyroid hormone production, and all the consequences of iodine deficiency stem from the associated hypothyroidism. Iodized oil is made by treating a fatty vegetable oil with iodine or hydriodic acid and is an effective long-term means of iodine supplementation. The type and fatty acids profile in the parent oil, as well as the way iodine is trapped, affect the physicochemical properties and effectiveness of the product. This research was conducted to study the effect of iodinated safflower oil on preventing iodine deficiency disorders (IDD) in livestock, compared with a commercial iodine supplement. Iodinated fatty acid ethyl esters prepared from safflower seed oil (IFAEESSO). Thirty Farahani ewes with a history of iodine deficiency were divided into three groups, including control and two treatment groups. The treatment groups received 390 mg of iodine by an intramuscular injection of 1.26 ml of IFAEESSO (n = 10) or 1.5 ml of Depodine® (n = 10), respectively. Serum iodine, thyrotropin stimulating hormone (TSH), T3 and T4 concentrations were assayed at baseline and every 30-day intervals over six months period. Iodine supplementation resulted in a significant increase in serum inorganic iodine over five months with Depodine and IFAEESSO (P