Implantable devices for optogenetic studies and stimulation of excitable tissue

• Published in: St. Petersburg Polytechnical University Journal. Physics and Mathematics 2015-10, Vol.1 (3), p.264-271
• Main Authors: Matveev, Maxim V., Erofeev, Alexander I., Terekhin, Stanislav G., Plotnikova, Polina V., Vorobyov, Konstantin V., Vlasova, Olga L.
• Format: Article
• Language: English
• Subjects: Action potential; Implanable opto-electrode array; Neurostimulation; Optical fiber; Optogenetics
• ISSN: 2405-7223; 2405-7223
• DOI: 10.1016/j.spjpm.2015.12.004

The paper deals with the currently available implants used in optogenetic experiments on laboratory animals in vivo. We present a brief description of the optogenetic investigation stages. Various types of implantable devices generating and recording signals in excitable tissues have been considered. The features of control signal transduction inside living tissues were analyzed. We discussed the possibility of medical and biological use of optical fibers for excitable tissues stimulation. Then we proposed a device of an implantable optical-electrode system for scanning and controlling the bioelectric parameters. The device can be used in medical diagnostics, prosthetics, myostimulation, neurostimulation and cardioacceleration, for instance, at neurological and rehabilitation medical institutions. With this in mind, an attempt will be made to make special combined microelectrode arrays to implant them into living tissue. The arrays should be able to change their profile according to the implantation-area contour and biophysical features of the substrate surface. It is necessary to provide a point generation and layer-by-layer scanning of excitation pulse through integration of individual microelectrode arrays into a single test-system.