The finite sample performance of the two-stage analysis of a two-period crossover trial

For subject and error variances assumed known, Freeman assesses the two-stage analysis of an AB/BA crossover trial. We provide a finite sample assessment of this analysis for the practical situation that these variances are estimated from the data.

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Bibliographic Details
Published in:Statistics & probability letters 2016-10, Vol.117, p.118-127
Main Author: Kabaila, Paul
Format: Article
Language:English
Subjects:
Crossover trial
Differential carryover
Large-sample approximation
Preliminary hypothesis test
Two-stage procedure
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Description
Summary:For subject and error variances assumed known, Freeman assesses the two-stage analysis of an AB/BA crossover trial. We provide a finite sample assessment of this analysis for the practical situation that these variances are estimated from the data.
ISSN:0167-7152
1879-2103
DOI:10.1016/j.spl.2016.05.011