Biotin deficiency and biotin excess: Effects on the female reproductive system

Biotin deficiency and biotin excess have both been found to affect reproduction and cause teratogenic effects. In the reproductive tract, however, the effects of biotin have not been well established yet. We investigated the effects of varying biotin content diets on the oestrus cycle, ovarian morph...

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Bibliographic Details
Published in:Steroids 2009-10, Vol.74 (10-11), p.863-869
Main Authors: Báez-Saldaña, Armida, Camacho-Arroyo, Ignacio, Espinosa-Aguirre, J. Javier, Neri-Gómez, Teresa, Rojas-Ochoa, Alberto, Guerra-Araiza, Christian, Larrieta, Elena, Vital, Paz, Díaz, Georgina, Chavira, Roberto, Fernandez-Mejia, Cristina
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biotin
Biotin - administration & dosage
Biotin - blood
Biotin - deficiency
Biotin - pharmacology
Body Weight - drug effects
CYP
Diet
Estradiol
Estradiol - blood
Estrous Cycle - drug effects
Female
Fundamental and applied biological sciences. Psychology
Liver - anatomy & histology
Liver - drug effects
Liver - enzymology
Mice
Mice, Inbred BALB C
Organ Size - drug effects
Ovary
Ovary - anatomy & histology
Ovary - drug effects
Progesterone
Progesterone - blood
Receptors, Estradiol - genetics
Receptors, Progesterone - genetics
Reproduction - drug effects
Reproduction - physiology
RNA, Messenger - genetics
RNA, Messenger - metabolism
Sex steroid receptors
Uterus - drug effects
Uterus - metabolism
Vertebrates: endocrinology
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Summary:Biotin deficiency and biotin excess have both been found to affect reproduction and cause teratogenic effects. In the reproductive tract, however, the effects of biotin have not been well established yet. We investigated the effects of varying biotin content diets on the oestrus cycle, ovarian morphology, estradiol and progesterone serum levels, and the uterine mRNA abundance of their nuclear receptors, as well as on the activity of the estradiol-degrading group of enzymes cytochrome P450 (CYP) in the liver. Three-week-old female BALB/cAnN Hsd mice were fed a biotin-deficient, a biotin-control, or a biotin-supplemented diet (0, 7.2 or 400μmol of free biotin/kg diet, respectively) over a period of nine weeks. Striking effects were observed in the biotin-deficient group: mice showed arrested estrous cycle on the day of diestrus and changes in ovary morphology. Estradiol serum concentration increased 49.2% in biotin-deficient mice compared to the control group, while the enzymatic activities of CYP1A2 and CYP2B2 increased (P
ISSN:0039-128X
1878-5867
DOI:10.1016/j.steroids.2009.06.004