Solubility of l-Dopa in supercritical carbon dioxide: prediction using a cubic equation of state

An alternative way is presented to evaluate the possibility of supercritical fluid extraction of a solute when no experimental data on solubility is available. To predict the solubility of l-Dopa (a drug commonly used for the treatment of Parkinson's disease) in supercritical CO 2, the Peng–Rob...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of supercritical fluids 2005-06, Vol.34 (2), p.231-236
Main Authors: Vieira de Melo, Silvio A.B., Vieira de Melo, Rosana L.F., Costa, Gloria M.N., Alves, Tito L.M.
Format: Article
Language:English
Subjects:
Caffeic acid
Cubic equation of state
l-Dopa
Solubility
Supercritical carbon dioxide
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An alternative way is presented to evaluate the possibility of supercritical fluid extraction of a solute when no experimental data on solubility is available. To predict the solubility of l-Dopa (a drug commonly used for the treatment of Parkinson's disease) in supercritical CO 2, the Peng–Robinson equation of state is applied in a fully predictive way with UNIFAC group contribution activity coefficient model incorporated in its mixing rules using the linear combination of Vidal and Michelsen (LCVM) procedure. Experimental solubility data of caffeic acid in SC–CO 2 is used as the reference basis for this methodology and the results for l-Dopa solubility suggest further experimental studies.
ISSN:0896-8446
1872-8162
DOI:10.1016/j.supflu.2004.11.019