Sustainable technologies for liposome preparation

• Published in: The Journal of supercritical fluids 2020-11, Vol.165, p.104984, Article 104984
• Main Authors: Maja, Leitgeb, Željko, Knez, Mateja, Primožič
• Format: Article
• Language: English
• Subjects: Liposome; Preparation; Supercritical fluids; Supercritical fluids assisted methods
• ISSN: 0896-8446; 1872-8162
• DOI: 10.1016/j.supflu.2020.104984

[Display omitted] •Sustainable green technologies for liposome preparation.•Production of micro‐ and nano‐sized liposomes with narrow size distribution.•Supercritical fluids assisted methods improve liposome encapsulation efficiency. Liposome possesses a great number of advantages and therefore they can be used for a variety of applications. Among other things, they can serve as useful drug carriers in preclinical and clinical trials. Supercritical fluids assisted technology is an appropriate method for liposome preparation because of its nontoxicity to the environment enables particle size manipulation and solvent-free production. Thus, the use of supercritical fluids (SCFs) provides advanced technology for liposome preparation and may become the dominant technology for their preparation in the future. This review discusses the classification of liposome and gives a short overview of their applications and conventional methods of preparation. Emphasis is placed on the use of various supercritical fluids assisted methods for liposome preparation and their advantages and disadvantages. The reader is also updated about recent developments in supercritical fluids assisted liposome production technology.