Rapid growth and regression of intracranial meningiomas in lymphangioleiomyomatosis: case report

Abstract Background Lymphangioleiomyomatosis is a progressive interstitial lung disease that affects young women. It has been suggested that estrogens play a role in its evolution, and progesterone therapy is often provided in these cases. Case Description We present a case of a postmenopausal woman...

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Published in:Surgical neurology 2007-12, Vol.68 (6), p.671-674
Main Authors: Pozzati, Eugenio, MD, Zucchelli, Mino, MD, Schiavina, Mario, MD, Contini, Paola, MD, Foschini, Maria Pia, MD
Format: Article
Language:English
Subjects:
Contraindications
Female
Humans
Lymphangioleiomyomatosis
Lymphangioleiomyomatosis - drug therapy
Lymphangioleiomyomatosis - pathology
Magnetic Resonance Imaging
Meningeal Neoplasms - chemically induced
Meningeal Neoplasms - pathology
Meningioma
Meningioma - chemically induced
Meningioma - pathology
Middle Aged
Neurology
Progesterone
Progesterone - adverse effects
Progestins - adverse effects
Surgery
Tuberous sclerosis
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Summary:Abstract Background Lymphangioleiomyomatosis is a progressive interstitial lung disease that affects young women. It has been suggested that estrogens play a role in its evolution, and progesterone therapy is often provided in these cases. Case Description We present a case of a postmenopausal woman with LAM treated with progesterone; subsequently, rapid growth of multiple intracranial meningiomas was observed. One prominent lesion was excised, and 3 other lesions regressed spontaneously over 2 years. Conclusions This is a rare case of a non–pregnancy-related regression of meningiomas in a woman affected by LAM. The significance of this association and the hormonal treatment of the disease are discussed.
ISSN:0090-3019
1879-3339
DOI:10.1016/j.surneu.2006.11.063