Combination therapy of vitamin C and phenolics-rich fraction of Khaya senegalensis stem bark extract against Trypanosoma brucei brucei infection

[Display omitted] The phenolics-rich fraction of Khaya senegalensis A. Juss (Meliaceae) stem bark extract (pfks) has been previously reported to possess potent antitrypanosomal activity at 300mg/kg body weight (bw) but could not completely prevent disease-induced anemia and organ damage in addition...

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Bibliographic Details
Published in:Synergy (Elsevier) 2017-06, Vol.4, p.19-22
Main Authors: Ibrahim, Mohammed Auwal, Musa, Aliyu Muhammad, Tairu, Hassanat Taye, Kassim, Maryam, Aliyu, Abubakar Babando, Tajuddeen, Nasir, Abdullahi, Hadiza Lawal, Habila, Nathan
Format: Article
Language:English
Subjects:
African mahogany
Anemia
Ascorbic acid
Organ damage
Trypanosoma brucei brucei
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Summary:[Display omitted] The phenolics-rich fraction of Khaya senegalensis A. Juss (Meliaceae) stem bark extract (pfks) has been previously reported to possess potent antitrypanosomal activity at 300mg/kg body weight (bw) but could not completely prevent disease-induced anemia and organ damage in addition to being slightly hepatotoxic at the same dose. Therefore, the effects of a combined administration of low dose pfks and vitamin C on the severity of Trypanosoma brucei brucei infection in rats were investigated. Daily oral administration of a combined treatment of pfks (100mg/kg bw) and vitamin C (100mg/kg bw) for seven days significantly (p
ISSN:2213-7130
2213-7130
DOI:10.1016/j.synres.2017.04.001