Ordered titanium templates functionalized by gold films for biosensing applications – Towards non-enzymatic glucose detection

Recently, metal nanostructures evoke much interest due to application potential in highly sensitive detectors in biochemistry and medical diagnostics. In this work we report on preparation and characteristics of thin (1–100nm) Au films deposited onto highly ordered structured titanium templates for...

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Bibliographic Details
Published in:Talanta (Oxford) 2017-05, Vol.166, p.207-214
Main Authors: Grochowska, Katarzyna, Szkoda, Mariusz, Karczewski, Jakub, Śliwiński, Gerard, Siuzdak, Katarzyna
Format: Article
Language:English
Subjects:
Au nanoparticles
Electrochemical activity
Glucose sensing
Surface enhanced Raman spectroscopy
Ti dimpled templates
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Summary:Recently, metal nanostructures evoke much interest due to application potential in highly sensitive detectors in biochemistry and medical diagnostics. In this work we report on preparation and characteristics of thin (1–100nm) Au films deposited onto highly ordered structured titanium templates for SERS (Surface Enhanced Raman Spectroscopy) and electrochemical sensing. The Ti templates are formed by selective removal of TiO2 nanotubes out of as-anodized titanium substrate. The surface of the obtained material reproduce precisely the bottom layer of the nanotubes and consists of a uniformly distributed dimples with diameter of ~100nm. For all structures covered with Au films the measured average SERS signal is markedly higher than the one observed for bare Ti templates. This is due to strong electromagnetic field in the vicinity of the film grains. Moreover, such nanostructured gold surface exhibits also attractive electrochemical and electrocatalytic properties, which should be attributed to enhancement of the electron transfer at the Au-Ti interface formed without any linker molecules. It is shown that prepared material can be used as an enzyme-free sensor for glucose detection in air-saturated neutral media especially in case of low sugar concentrations present in human body liquids, such as saliva, sweat and interstitial fluid. [Display omitted] •Densely arranged and highly organized dimpled Ti substrates for glucose sensing were produced.•SERS substrates demonstrate enhanced Raman sensitivity.•Electrochemical measurements indicate on promising sensing material.
ISSN:0039-9140
1873-3573
DOI:10.1016/j.talanta.2017.01.075