Thermal stability of solid dispersions of naphthalene derivatives with β-cyclodextrin and β-cyclodextrin polymers

• Published in: Thermochimica acta 2006-05, Vol.444 (1), p.57-64
• Main Authors: García-Zubiri, Íñigo X., González-Gaitano, Gustavo, Isasi, José Ramón
• Format: Article
• Language: English
• Subjects: Chemistry; Condensed benzenic and aromatic compounds; Cyclodextrin polymers; Cyclodextrins; Exact sciences and technology; Naphthalenes; Organic chemistry; Preparations and properties
• ISSN: 0040-6031; 1872-762X
• DOI: 10.1016/j.tca.2006.02.024

The thermal stabilities of some naphthalene derivatives (1-naphthyl acetate, 2-acetylnaphthalene, 1-naphthol) in β-cyclodextrin (β-CD) inclusion complexes and in β-CD-containing polymeric systems (Polyβ-CD) have been studied using thermal and thermogravimetric analyses and infrared spectroscopy. In β-CD systems, the stability of the 1-naphthyl acetate complex is lower than that of the 2-acetylnaphthalene complex, and both are more stable than the corresponding physical mixtures. For Polyβ-CD systems, the solid dispersions result much more stable than the corresponding β-CD ones, both at room temperature and at 60 °C. In the case of Polyβ-CD, besides the inclusion within CD cavities, the interaction of the guest with the crosslinking network confers an additional stability against volatilization. In contrast, an analogous crosslinked polymer prepared using sucrose instead of β-CD does not retain noticeable amounts of the naphthalene derivatives.