Isothermal microcalorimetry perfusion experiments: A method to verify the relative vapour pressure of organic liquids inside the sample vessel

Perfusion microcalorimetry is frequently applied to expose pharmaceutical solids to specific relative vapour pressures (RVP) of organic liquids or water. The aim was to set up a general procedure to check the performance of a vapour pressure control device used to create a specific RVP. This was ach...

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Bibliographic Details
Published in:Thermochimica acta 2009-09, Vol.493 (1), p.37-41
Main Authors: Baronsky, Julia, Bongaerts, Sabine, Traeubel, Michael, Urbanetz, Nora
Format: Article
Language:English
Subjects:
Analytical chemistry
Chemical and thermal methods
Chemistry
Exact sciences and technology
Isothermal microcalorimetry
Perfusion
Relative vapour pressure
Vapour sorption
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Summary:Perfusion microcalorimetry is frequently applied to expose pharmaceutical solids to specific relative vapour pressures (RVP) of organic liquids or water. The aim was to set up a general procedure to check the performance of a vapour pressure control device used to create a specific RVP. This was achieved by identifying and checking the significant factors in the creation of the RVP inside the reaction vessel. The flow switch valve was tested by volume flow measurements whereas the saturation of the wet line was verified in a calorimetric experiment employing methanol as model solvent. The results of the measurements were used to calculate the RVP inside the reaction vessel. The method developed is suitable to test the vapour pressure control device. It can be applied for any solvent.
ISSN:0040-6031
1872-762X
DOI:10.1016/j.tca.2009.04.001