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Putting transcriptional brakes on fibrosis: a negative regulator of TGFβ signaling

Due to the pleiotropic effect of transforming growth factor β (TGFβ) signaling inhibition, function-specific targeted inhibition of TGFβ signaling is required. In a recent study, Yang et al. found that Krüppel-like factor (KLF)-13 acts as a negative regulator of TGFβ. Thus, activating KLF13 in fibro...

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Bibliographic Details
Published in:Trends in cell biology 2023-09, Vol.33 (9), p.734-735
Main Authors: Rohil, Ayanna, Talekar, Siddhi, Shammas, Khalid M., Ajay, Amrendra K.
Format: Article
Language:English
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Summary:Due to the pleiotropic effect of transforming growth factor β (TGFβ) signaling inhibition, function-specific targeted inhibition of TGFβ signaling is required. In a recent study, Yang et al. found that Krüppel-like factor (KLF)-13 acts as a negative regulator of TGFβ. Thus, activating KLF13 in fibrotic tissues may protect them from fibrosis by decreasing TGFβ signaling.
ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2023.06.003